Posted by bretbe on April 17, 2003, at 0:26:19
In reply to Please help with my list of promising future drugs, posted by Shawn. T. on April 13, 2003, at 18:59:16
Question:
I'm not real savvy here on all the technical psychopharmocological aspects here, but I'm very interested in what you've found on GABA and what you said about Lamictal. I had a very bad reaction to Lamictal, similar to what I had with Welbutrin, Lithium, and Buspar, in that my anxiety went out the roof...intense, wound up pressure that I thought head would explode...SUBJECTIVE FEELING, not actual physical symptoms such as hypertensive crises...mental pain all the way. Anyway, the only med that has had any significant positive effect is Klonopin and, as I understand it, Benzo's work on the GABBA system...perhaps. Anyway, my question is about your statement about Lamictal was your comment about negatively impacting GABBA. It appears that highly activating meds make my symptoms worse (intense mental anxiety, dysphoria & non-depressed depression, i.e., normal energy but doom and gloom in head), while benzo's take some of the sting out. Also, valproic acid (Depakote) initially felt nice at low doses and supposedly works as GABBA agonist. Sooo, could it be that my particular variant of depression/anxiety is primarly related to GABBA? I mean, does it make any kind of sense, based on your info, that low GABBA is my problem while augmenting GABBA is my cure?Any thoughts based on your research?
poster:bretbe
thread:219077
URL: http://www.dr-bob.org/babble/20030411/msgs/219961.html