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Re: Mirapex PuraVida

Posted by not exactly on April 8, 2003, at 3:04:29

In reply to Re: Atomoxetine (Straterra) as a stimulant , posted by PuraVida on April 7, 2003, at 22:47:10

> Question - apparently Mirapex is a dopamine reuptake inhibitor mainly used for Parkinson's, but I have seen on this site some people have used it for depression. Has anyone here tried it? Any info on doses/results is appreciated.

Mirapex (pramipexole) is a dopamine (primarily D3) agonist (NOT a reuptake inhibitor). Its only FDA-approved use is for treating Parkinson's Disease. It was tested for effectiveness as an antidepressant (I was a volunteer in one of the early trials) but it failed to win FDA approval for that use.

In the trial, participants were randomly (double-blind) assigned to one of four groups: 7mg/day, 3mg/day, 1mg/day, or placebo. The drug was administered orally b.i.d. I was in the 1mg/day (0.5mg/dose) group (I didn't know my dose during the trial; they were able to tell me years later).

It was a miracle drug for me. Completely cured my depression and ADD almost immediately! But after the trial, my depression & ADD returned just as quickly. Unfortunately, since pramipexole was not yet approved, they couldn't prescribe it to me. So I went for years trying many other antidepressants, but none worked anywhere near as well (most made me feel worse).

When Mirapex was finally approved (for Parkinson's only, but at least it could be prescribed), I tried it again. Alas, it didn't work as well as it had years before, and finally "pooped out" completely after several months. Bummer.

My theory is that, because it's an agonist, the brain down-regulates the dopamine receptors to compensate, so eventually the benefit wears off.

- Bob




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