Posted by Larry Hoover on April 7, 2003, at 9:39:59
In reply to Re: TMG » Larry Hoover, posted by Ron Hill on April 7, 2003, at 0:50:21
> Larry,
>
> > > As I mentioned to you previously, about a year ago I had five months of good results using 200 mg/day of SAM-e to treat the atypical depressive phase of my BP II disorder. But then, rather suddenly, it started to make me VERY irritable (GRRRRRRRRRRRRRRRR!).
>
> > The other possibility involves the whole concept of taking fully active exogenous substances, such as SAMe (or 5-HTP). In doing so, you bypass the normal regulatory processes which govern the concentration of these potent molecules. Perhaps, over five months, you gradually increased the concentration of one of the products of SAMe-dependent reactions because you kept taking it every day, and that product led to irritability. Your body will have a number of feedback inhibition signals which would have been activated by the increased product concentration; these would have been to no effect because the daily SAMe supply was independent of feedback control. My intuition lies with this latter explanation. Maybe you took too much/over too long a period of time.
>
> Larry, would you expect that I would have the same problem if I were to take TMG instead of SAM-e?No, I think not. We're deep into speculation, though.
> Enough about me, lets talk about you for a minute. Is the Enada NADH providing any on-going benefit for you?
I think it has. My pattern, established and reinforced over years now, has been that I slump after any prolonged exertion. I can't work a full-time job of any sort because of this. I've been lucky enough to find an employer who will take from me all that I can give them. In essence, I've been working one month on, one month off. The month off has been characterized by profound fatigue, cognitive and memory problems, irritabliity, mood decline. I'm usually already starting the slide before I even finish the month on, and the minimum takes a further two weeks to fully develop. I don't seem to be having this happen to me this time. I'm a little low, but it's not what I've come to expect.
I've been taking the NADH quite irregularly after that first week. It certainly had a cumulative effect, and I feared having taken too much. Anyway, I think it's helped. Too soon to be conclusive, but there's a positive trend.
> Okay, the minute’s up; back to my issues. What is your opinion of the information in one of the articles posted by JLx addressing the cortisol:DHEA hormonal ratio issue? More to the point, what is your position regarding DHEA supplementation as a method of balancing out elevated cortisol levels? For some time now, I have been interested in low dose DHEA supplementation. However, I’ve held off on conducting the trial because of what I have here-to-fore perceived to be risky manipulation of hormone levels. Here is the link to the article: http://www.drdebe.com/fitness.htm
>
> -- RonYa, I know. Hormones are potent. Hormones are tricky. Still, 50 mg of DHEA isn't going to do too much adverse, even if you didn't need it.
My intuition has led me to take "pulses" of some of the stimulating supplements. Little bursts of enhancement, rather than chronic supplementation. I feel more comfortable with one finger on the scale, rather than my fist.
Lar
poster:Larry Hoover
thread:215282
URL: http://www.dr-bob.org/babble/20030407/msgs/216945.html