Posted by jemma on April 4, 2003, at 11:54:09
In reply to Re: hypercalcemia, posted by Larry Hoover on April 3, 2003, at 18:26:38
> > This is interesting to me. I have ndi - nephrogenic diabetes insipidus - which has caused hypercalcuria and high blood phosphate, low sodium, etc. I control it with 25 mg. of hydrochlorthiozide. Because of ndi, I can't take lithium, which causes ndi in many people. So Mitch, your hypercalcemia may have been a result of lithium.
>
> Fascinating that a diuretic controls a disorder of diuresis. Have you ever been advised to use an NSAID? The combination is more effective than the thiazide alone.
I'll ask my endo about this - thanks.
>
> > Larry, how does any of this affect my meds? Currently I take 250 mg modafinil and 10 mg selegiline, along with the hydrochlorthiozide and HRT.
>
> None of these should be affected by your kidney disorder. Surely you were dose-titrated with foreknowledge of the NDI, yes?
>
Actually, I pretty much titrate the doses myself. After so many meds over the years, I've developed a pretty finely honed sense of what I need to feel well. And modafinil and low-dose selegiline aren't meds that my psychopharmacologist has much experience with.> >I've often wondered if my brain fox came from a lack of vasopressin receptors in my hypothalamus, as well as my kidney.
>
> Were your psychotropic meds prescribed to deal with brain fog, in particular? They seem to be appropriate for that.I found these meds and sold my pdoc on them. But yes, my depression is of the anhedonic, anergic, brain fog variety. Ssri's made things worse - after nine years on zoloft I discovered it had been downloading catecholamine receptors. Serzone turned me into a blithering idiot, and lamictal wasn't much better. Even wellbutrin made me fall asleep. Finally we tried modafinil, and voila - energy and motivation for the first time in a decade. Then he tried ritalin and it felt like valium, but with a wicked rebound effect. So I talked him into the selegiline, and its working a treat.
>
> As I understand it, the hypothalamus senses solute concentrations directly, and thus mediates vasopressin release, rather than responding to it. Or have I got that mixed up?Like most things neurochemical, the V2 receptors seems to be pretty much a mystery. I do know that vasopressin not only prevents diuresis but also sharpens the mind and memory brilliantly.
>
> > My ndi appears to be genetic, but it's labelled idiopathic for 'who knows?'
>
> Ya. I hear ya. If experts don't know, who does?
>
> >I've had a lot of weird things go wrong, including postcapsular cataracts. I'm 47, and not diabetic.
>
> Well, I hate to say it, but you're of an age where things, idiopathic things, tend to become prominent.Don't I know it. Like a car, wearing out its parts one by one. Damn, I wish I'd spent more time on early maintenance :^). Still, I have a lot of pretty weird things going on.
>
> > Feel free to ignore this. But I've come to admire the scope of your knowledge of the brain's and body's chemistry.
> >
> > - jemma
>
> I will always be a student. I have an infinite curiosity. Glad to find that suits others, too.
> ;-)
>
> LarLucky for us. Thanks, Larry.
- jemma
poster:jemma
thread:215138
URL: http://www.dr-bob.org/babble/20030402/msgs/216192.html