Posted by Ilene on March 12, 2003, at 20:32:59
In reply to Re: need for atypical depression research » Ilene, posted by Shawn. T. on March 12, 2003, at 19:08:30
> I forgot to reply to a couple things. Forgive me if the following is obvious. With the hereditary relationships that you speak of, the effect is likely a result of susceptibility genes that contribute to several different disorders. Depending on neurodevelopmental factors and the existence of other susceptibility genes, one particular gene can be involved in several disorders. In addition, studies occasionally find "modification" type genes that alter or negate the effects of a certain susceptibility gene.
>Yeah, I know. It's complicated.
For many years I thought my mother had a masked mood disorder. Stress triggered her migraines; and she was ... strange.
It wasn't until recently that I discovered there was a correlation between migraine & depression (or was it BP? not worth checking right now), not only in an individual, but in the family.
I don't remember what all the disorders are supposed to be, but I remember migraine was there, and irritable bowel syndrome. Migraine is supposed to be caused by serotonin; I wonder if there is a relationship between IBS & serotonin, given that there is so much of it in your gut. Just haven't been curious enough to research it.
So how does a "susceptibility" gene work? What does it make? How does it affect different disorders? And what's a "modification" gene?
> Regarding the articles without abstracts, my snobbish attitude is that a research article should have an abstract if is worth reading; most major journals require them anyway. When I search PubMed, I typically use the feature that leaves out articles without abstracts. A trip to the NLM would be a nice way around the unbelievable prices for journals. There's a big push among some people to have more free articles made available; hopefully this concept will take hold eventually.
>
> ShawnYes, I am familiar w/ the problems regarding journal subscriptions. Haven't paid attention for the last year and 1/2. People don't realize how expensive they are. Even less expensive would make them more accessible.
There are problems w/ using PubMed as your sole bibliographic database, plus there are internal problems w/ it. I love it anyway.
--I.
poster:Ilene
thread:207835
URL: http://www.dr-bob.org/babble/20030310/msgs/208559.html