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Re: Enada NADH for BP II Atypical Depression » ShelliR

Posted by Ron Hill on March 7, 2003, at 18:52:02

In reply to Re: Enada NADH for BP II Atypical Depression » KrissyP, posted by ShelliR on March 7, 2003, at 15:54:56

Hi Shelli

> I'd really like to know your dosing, if you don't mind. I think I'm going to try NADH.

Please remember that I’m in the early stages (sixth week) of this Enada NADH trial, so these results should be treated as preliminary in nature. Here’s what I have experienced so far.

I started out taking 10 mg/day of the sublingual formulation (EnadAlert NADH). I felt my atypical depression (low motivation, anergy, anhedonia, hypersomnia) and dysphoric mood states (extreme irritability) begin to lift within thirty seconds after placing the sublingual tablet under my tongue. Within three days, my depression and dysphoric mood states were in complete remission. It snapped me out of a three-month-long deep depressive cycle that I just could not pull myself out of.

After ten days, however, this dose (and formulation) induced irritability. So I switched to the enteric-coated Enada NADH “down-the-hatch” formulation. I took one of the 5 mg tablets per day. The irritability immediately stopped and the remarkable AD benefits continued.

However, four weeks into the trial I began to get VERY sleepy about four hours after my dose. Therefore, I skipped my dose for two days. The sleepiness went away on the first skipped day and the positive benefits remained.

For the past two weeks, I have been experimenting with my dosing schedule to find the optimal maintenance dosage for my body. When using 5 mg tablets, the schedule that seems to work best for me is to take 5 mg on day one, skip days two and three, and repeat the sequence starting on day four. When I tried skipping three days, my dysphoric mood states and low motivation begin to reappear on the third skipped day. I ordered some 2.5 mg tablets and they arrived yesterday. My plan is to try 2.5 mg every other day starting tommorrow.

Ray Sahelian, M.D., in his book titled "Mind Boosters: A Guide to Natural Supplements that Enhance Your Mind, Memory, and Mood", recommends taking no more than 2.5 mg two or three times per week. His main concerns regarding higher doses are the potential for building a tolerance to NADH and that the medical community doesn't know a lot about this stuff yet. My preliminary assessment is that I'll probably end up taking about 2.5 mg three times per week as a maintenance dose. Time will tell with regard to the dose and whether this stuff has any long-term efficacy.

This may have been more information than you wanted. I can get a little long winded. Knowing what I know now, I would have started by taking 5 mg/day of the enteric-coated product for a week or so to get a kick start, and then I’d titrate down to 2.5 mg every other day. But everyone is unique so your mileage (and dosage) may vary.

-- Ron


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