Posted by ace on March 3, 2003, at 20:27:32
In reply to Re: MAOI and OCD » DavidLA, posted by DavidLA on March 2, 2003, at 23:59:23
> > OK, I'm in the same position. Nardil has worked on my OCD about 50-60% on 90mg at around 6 weeks. (Been on Nardil total 13 weeks).
> > It has definately helped OCD but not good enough.
>
> Nardil doesn't do *anything* for my OCD. That's why I'm looking to compliment it with another med.OK..let's sort this out. First of all, if the Nardil is working for other probs, keep it.
Ist sounds as if you will definately have to augment, or as you say, compliment it.
> > I am raising dose to 105mg for 4 weeks. If this don't work 120mg for another 4 weeks. If this doesn't work we will then augment Nardil with Zyprexa and then Risperidone (If Zyprexa doesn't work)
>
> Are these meds you mention for OCD? I'm not really caught up on meds these days, besides Nardil.The two meds I mention are used mostly to augment anti-OCD's, such as Prozac, Zoloft etc. BTW, I had no success with these drugs. Sometimes the above two meds are used on their own for OCD. You must be aware that these are anti-psychotic meds - they are used a lot for people with psychotic illness. BUT, these two are from the newer generation and are now used a lot for panic d/o, ocd etc. Be aware, after long times at high doses they can cause a s/effect called Tardive Dyskinesia. This is a neurological prob which causes uncontrollable tongue thrusting, jerks etc. But don't be scared - keep the dose low. I heard of one lady on an older generation anti-psychotic (Thorazine) for Panic for 10 years low dose -- She had NO probs whatsoever and Thorazine is MUCH worse for that s/effect.
I have read many journal articles where Zyprexa and Risperidone has wiped out OCD 100% so keep faith.
> > What dose are you on and how long?
>
> 4+ years. I'm on a maintenance dosage of less than 45mg now. Nardil has not helped my OCD at any dose, though. Actually, for me, lower doses of Nardil helped my Depression & Social Phobia more than higher doses did...have you tried that route already?No, might in future, but just raised my dose. Higher doses work better for me I think.
Initially I tried Nardil at 75-90mg and had only modest results. A year later I tried it at 45mg for a sustain period and it worked wonders.
Don't stop Nardil then!!!!
> > I suggest if you have been on high dose long enough augment with atypical antipsychotics, Gabapentin, or desipramine (A TCA which is sake with Nardil -- it only affects Noradrenaline).
>
> Again, I'm not aware of these meds. Can you explain each of their characteristics? I'm looking for something that targets a compulsive, repetitive behavior.Atypical antipsychoics are the two I mention above. Bapapentin is a mood stabilizer and desipramine is a Trycyclic anti-depressent.
Gabapentin is relaxing and has been used successfully in augmentation for OCD. I am not aware of desipramine for OCD augmenter but it's worth a try.I would do the below. Of course this is just my opinion I've gleaned from much research. Show your doctor obviously.
1. Nardil + Zyprexa (low dose)
if doesn't work...
2. Nardil + Risperidone (low dose)if doesn't work...
3. Nardil + Gapapentin4. Try Parnate
5. Parnate + Zyprexa (low dose)
if doesn't work...
6. Parnate + Risperidone (low dose)if doesn't work...
7. Parnate + Gabapentin.Of course, give each trial sufficient time. Don't worry, even after this there is plenty more to try. BTW, I have heard some people have BRILLIANT results on Parnate for OCD. (Parnate is the other MAOI, of course) Just cause Nardil doesn't kill OCD, doesn't mean Parnate won't.
> Many Thanks,
> DLANo worries! Keep in touch!
Ace.
Nardil, 105mg.
poster:ace
thread:205025
URL: http://www.dr-bob.org/babble/20030301/msgs/205645.html