Posted by not exactly on February 7, 2003, at 13:00:44
In reply to Re: Anybody else sedated on Straterra? Please respond, posted by sjb on February 7, 2003, at 11:49:16
> Does anyone know what that half life is?
short answer: typically 5 hours, but can be as much as 24 hours
long answer, from the official "prescribing information" document:
Human Pharmacokinetics
Atomoxetine is well-absorbed after oral administration and is minimally affected by food. It is eliminated primarily by oxidative metabolism through the cytochrome P450 2D6 (CYP2D6) enzymatic pathway and subsequent glucuronidation. Atomoxetine has a half-life of about 5 hours. A fraction of the population (about 7% of Caucasians and 2% of African Americans) are poor metabolizers (PMs) of CYP2D6 metabolized drugs. These individuals have reduced activity in this pathway resulting in 10-fold higher AUCs, 5-fold higher peak plasma concentrations, and slower elimination (plasma half-life of about 24 hours) of atomoxetine compared with people with normal activity [extensive metabolizers (EMs)]. Drugs that inhibit CYP2D6, such as fluoxetine, paroxetine, and quinidine, cause similar increases in exposure.[the complete document can be downloaded from http://pi.lilly.com/us/strattera-pi.pdf]
- Bob
poster:not exactly
thread:133458
URL: http://www.dr-bob.org/babble/20030204/msgs/139985.html