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Re: Straterra -Second Day -tia

Posted by BekkaH on January 18, 2003, at 21:44:17

In reply to Re: Straterra -Second Day, posted by tia on January 18, 2003, at 17:09:31

>I dont know if its in my head or what but i feel >like the anxiety is back again. I think its just >the medicine change, because it says on the >package sheet that it is one of the side effects >so i hope it goes away. I am not giving up yet.
> I am not sure how long the wellburtrin takes to >get out of my system so i am sure the two >medicines are clashing.
Regarding Wellbutrin: The AVERAGE half-life of bupropion (the generic name of Wellbutrin) is about 14 hours; HOWEVER, bupropion has several metabolites (substances it is broken down into in the body) that have much longer half-lives. I don't have the exact numbers in front of me at the moment, but if I remember correctly, one of the metabolites has an average half-life of approximately 37 hours. Since these are averages, there is a wide range that can vary according to a number of factors, including concomitant medications and the liver's ability to metabolize the medications. As you probably know, the half-life is the time it takes for HALF of the substance to leave your body. I don't know how Strattera interacts with Wellbutrin, but since they both block the reuptake of norepinephrine, which can cause anxiety, I believe the likelihood of each one potentiating the other's anxiogenic effects is quite high. I hope you do well on Strattera. Medicines like this are long overdue.




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