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Re: more Omega-3 questions

Posted by Noa on January 18, 2003, at 12:00:42

In reply to Re: more Omega-3 questions judy1, posted by Noa on January 18, 2003, at 11:33:29

Here are results from my pub med search, and any assistance in udnerstanding or interpreting the info is welcome!!


Phospholipid metabolism and depression: the possible roles of phospholipase A2 and coenzyme A-independent transacylase.

Horrobin DF.

Laxdale Research, Kings Park House, Laurelhill Business Park, Stirling, Scotland FK7 9JQ, UK

*excerpt* from the abstract:

".....They are essential for neuronal and especially for synaptic structure and play key roles in the signal transduction responses to dopamine, serotonin, glutamate and acetyl choline. The unsaturated fatty acid components of phospholipids are abnormal in depression, with deficits of eicosapentaenoic acid and other omega-3 fatty acids and excesses of the omega-6 fatty acid arachidonic acid..."


For the above, I did not paste any text because this was very chemistry oriented and hard to understand. However, if someone who can understand it wants to look at it and try to explain it to me (us) that would be great--it seemed to have some info about fish oil and serotonin. Thanks.


The role of dietary n-6 and n-3 fatty acids in the developing brain.

Innis SM.

Here is the abstract:

Department of Paediatrics, University of British Columbia, Vancouver, B.C., Canada.

The dietary requirements for essential fatty acids and the possibility of a specific role for the polyunsaturated fatty acid docosahexaenoic acid (DHA) is one of the most controversial areas in infant nutrition. DHA is found in unusually high concentrations in the brain and is selectively accumulated during fetal and infant brain growth. DHA can be synthesised through a complex series of chain elongation-desaturation reactions from alpha-linolenic acid, but the efficiency of this process in young infants is not clear. Clinical studies on the potential benefits to neural development of dietary DHA have yielded conflicting results. Recent studies have provided evidence that plasma DHA is available to developing brain and that DHA is involved in dopamine and serotonin metabolism. These findings should guide clinical studies to more sensitive measures of the functional roles of dietary n-3 fatty acids and to clinical conditions where n-3 fatty acids may have benefit. Copyright 2000 S. Karger AG, Basel




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