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Re: Low Thyroid and lithium - not a good combo BarbaraCat

Posted by Ritch on January 14, 2003, at 23:22:32

In reply to Re: Low Thyroid and lithium - not a good combo Ritch, posted by BarbaraCat on January 14, 2003, at 13:14:32

> Hi Mitch,
> Thanks for replying. Depakote, huh. I don't think I'm getting the right response to lamictal anymore and don't tolerate ADs very well - been on all of them as well as the SNRI's and end up with mixed states everytime. Anxiety is a major component and I have way too much real honest to God stress in my life. I've been on all the benzos and clonezapam is probably the best, but it causes doldrums and I think my GABA receptors are clogged anyway. I understand Depakote helps smooth things out, but how does it do as an AD?. Do you have personal experience with it?
> I'm really trying to minimize the little bit of this and that drug cocktail syndrome but would augment if necessary as long as it's not an SSRI. I'm still dealing with weight gain from Remeron (no longer taking that dud) and lithium -- just replacing one porkogenic substance with another, so the weight gain issue is moot. - BarbaraCat

Barb, that sounds sooo familar. Depakote works as an "AD" for me *only* when I am predominantly experiencing mixed symptoms like you get. It takes away the agitation and hostility and that lifts my mood. However, during my seasonal major depressions (twice a year), I've got to add *something* to keep from sleeping too much (which Depakote is AGGRAVATING) otherwise the resulting hypersomnia snowballs and intensifies the depression. I tried reducing the Dep. dosage this time around and I slept more normally, but I was also more agitated. This is a total stab in the dark, but... you might find that a *little* Depakote (with a careful and observant cross-taper with lithium) with your thyroid augmentation and continuing with your Lamictal might work out very well. Just keep in mind that if you add some Depakote that will cause your Lamictal blood levels to rise (for good or ill). I've got this hunch that since Depakote works so well for my agitative, mixed, hostile episodes, and that Lamictal works so well for depression, and thyroid augmentation helps for rapid-cycling, that a combo of Depakote+Lamictal+thyroid might be a decent solution.----Mitch




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