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Re: Xanax and Klonopin. Madness! viridis

Posted by Franz on January 10, 2003, at 8:20:32

In reply to Re: Xanax and Klonopin. Madness!, posted by viridis on January 9, 2003, at 23:30:14

BrittPark, viridis, will you read my original post again?.
I am talking about alprazolam and clonazepam as particular benzo, supposed to have an action on serotonine

My reasoning was;

use of LSD which acts on serotonine right? btw maybe this person selected LSD because of a serotonine problem?
problems with serotonine
problems with alpra and clon-zepams, which are supposed to act in SOME way on serotonine
ergo: maybe they are the wrong benzo to use in this case if there are problems with serotonine derived from LSD use.
just speculation, but what else can we do?

Clonazepam is a benzodiazepine, anticonvulsant medication. It is generally used for the prophylaxis of seizures. It has unlabeled uses for neuralgia, acute manic episodes, and adjunct therapy for schizophrenia. It has been hypothesized that clonazepam may be useful in the treatment of OCD. This drug has an effect on serotonergic activity by up-regulating the 5-HT-1 receptor sites.
http://lynx.dac.neu.edu/e/ekrenzel/OCDdrug.htm

clonazepam is a facilitator of gamma-aminobutyric acid system, and
also increases central synthesis of serotonin,
dopamine and noradrenaline, and mimics the effect of
the neurotransmitter glycine. This is a combination
of effects that may offer antidepressive action.
http://www.depression.org.uk/main/pdf/treatmedication8.pdf

clonazepam
Klonopin, Rivotril
anxiolytic, anticonvulsant, hypnotic, bipolar disorder, agoraphobia, panic disorder, Lennox- Gastaut Syndrome
anxiety: 0.5- 4mg
AC: 1.5- 10mg
(20mg max)
* 3-hydroxy benzodiazepine:
BZD agonist
5-HT increase

alprazolam
Xanax, Ansiopax, Apotex, Constan, Mialin, Pazolam, Tafil, Tranquinal, Xanor, Zanapam
anxiety, GAD, panic disorder
1.5-4.0mg
(10mg max)
* triazolo benzodiazepine:
BZD agonist
5-HT release

http://sl.schofield3.home.att.net/medicine/psychiatric_drugs_chart.html

also,cygnusx1
> I tried taking the same level of Klonopin

what does that mean? clon is twice as potent as alpra as I read someplace and can tell from experience

>and felt even worse than on Xanax. Very jittery and I couldn't talk properly. Like I wanted to say 5 words at once.

serotonine mediated anxiety?, I read something about that but I will let you search yourself.

HIH


> BrittPark's explanation is right -- benzos bind to sites on a receptor on the surface of certain nerve cells that, in turn, send messages to other nerve cells. Binding of benzos increases the affinity of the receptor for the neurotransmitter gamma-aminobutyric acid (GABA). GABA regulates the activity of these cells, essentially making them less likely to send out "emergency" signals that provoke an anxiety response when there really isn't an emergency. Anxiety disorders (and some forms of epilepsy) are thought to result from hyperexcitability of the GABA-sensitive neurons, probably because they aren't effectively binding enough GABA and thus aren't being adequately regulated.
>
> There's probably some connection with the serotonin system (most of these neurotransmitters affect one another in some way), but as far as I know, benzos don't act directly on serotonin levels or binding.

 

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poster:Franz thread:135035
URL: http://www.dr-bob.org/babble/20030106/msgs/135170.html