Posted by Shawn. T. on January 3, 2003, at 17:33:45
In reply to Re: I do believe in norepinephrine (and CRF) » Shawn. T., posted by Ritch on January 3, 2003, at 10:16:35
You're welcome. I believe that several studies have linked increased levels of MHPG to agressivity. Alpha-2 antagonists increase MHPG, or general rates of norepinephrine turnover. The activation of alpha-1 adrenoceptors has been linked to heightened aggression. I believe that the increased norepinephrine tone secondary to alpha-2 antagonism leads to activation of alpha-1 receptors. Unlike beta-2 adrenoceptors, the responsiveness of alpha-1 receptors increases after treatment with drugs that increase levels of extracellular norepinephrine. I don't believe that alpha-1 induced aggression involves involves CRF. It's tough to speculate on how alpha-1 activation might lead to aggression/rage; I suspect that they may have excitatory actions on hypothalamic neurons mediating the control of aggressive behavior.
poster:Shawn. T.
thread:133959
URL: http://www.dr-bob.org/babble/20021230/msgs/134360.html