Posted by cybercafe on December 22, 2002, at 21:24:52
In reply to Re: do anti-psychotics make ADD worse?? » cybercafe, posted by Ritch on December 22, 2002, at 18:12:53
> > i was taking zyprexa+clonazepam for bp II, then when we threw in
> > 30 mg of ritalin sr it seemed to do little
> >
> > do anti-psychotics make ADD worse, or make stimulants less effective?
> >
> >
>
>
> They make stimulants less effective. If you are taking enough of an AP, your D2 receptors are all pretty much going to be blocked and a stimulant would likely have little effect. They can make ADD symptoms worse, too. I remember when I was trying low-dose Seroquel at bedtime, I would have a rebound super-attentive effect about 16 hrs. post-dosing, when the D2 receptors were becoming unoccupied.
>damn... actually i was reading an article on the journal of clinical psychiatry that implicated D4 receptors ...
and apparently olanzapine binds strongly to D4 receptors
but then i thought norepenephrine was also important in
ADD....what is the mechanism of action of ritalin, just
inhibition on the dopamine re uptake transporter?
poster:cybercafe
thread:132899
URL: http://www.dr-bob.org/babble/20021217/msgs/132941.html