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Drug/drug and drug/food interactions

Posted by Larry Hoover on December 7, 2002, at 13:29:06

This subject comes up repeatedly, but it's one of the hardest to grasp, and most doctors don't have a clue. The link below has some excellent tables, and also some really good descriptions of the sort of thing that can go on, vis a vis interactions.

Some terminology that's essential:

substrate: any substance consumed by an enzyme. The enzyme reduces the concentration, and changes the substance to something else. A substance which is metabolized by an enzyme is a substrate for that enzyme. They mean the same thing. Two different tables use these equivalent terms.

inhibitor: any substance which slows down the action of an enzyme. The net effect is the same as taking too much of any drug which is a substrate for that enzyme.

inducer: any substance which speeds up the activity of an enzyme. The net effect is the same as taking too little of any drug which is a substrate for that enzyme.

http://www.erowid.org/psychoactives/pharmacology/pharmacology_enzymes1.shtml

 

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poster:Larry Hoover thread:130925
URL: http://www.dr-bob.org/babble/20021203/msgs/130925.html