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Re: Positive BPClinical Trial for Nutritional Product

Posted by Larry Hoover on December 4, 2002, at 8:02:35

In reply to Positive BPClinical Trial for Nutritional Product , posted by McPac on December 4, 2002, at 0:59:30

> This product is called E.M. Power+
>
> 1: J Clin Psychiatry 2001 Dec;62(12):936-44 Related Articles, Links
>
>
> Comment in:
> J Clin Psychiatry. 2001 Dec;62(12):933-5.
>
> Effective mood stabilization with a chelated mineral supplement: an open-label trial in bipolar disorder.
>
> Kaplan BJ, Simpson JS, Ferre RC, Gorman CP, McMullen DM, Crawford SG.
>
> Faculty of Medicine, University of Calgary, Alberta Children's Hospital, Canada. kaplan@ucalgary.ca
>
> BACKGROUND: To determine in open trials the therapeutic benefit of a nutritional supplement for bipolar disorder. METHOD: The sample consisted of 11 patients with DSM-IV-diagnosed bipolar disorder aged 19 to 46 years, who were taking a mean of 2.7 psychotropic medications each at study entry. Three additional patients dropped out prematurely.

From a methodological perspective, open trials are at best suggestive, at the worst, useless. In an open trial, both the subject and the observers are aware of the treatment, providing all sorts of opportunities for conscious and subconscious bias. Also, failure to account for the 3 of 11 dropouts in statistical analyses artificially increases the outcome measures.

I review published work like this for a living. I'm not picking on Empower+.

 

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poster:Larry Hoover thread:130475
URL: http://www.dr-bob.org/babble/20021203/msgs/130496.html