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Re: AUGMENT PROZAC OR SWITCH SSRI » freedom2001

Posted by hiba on November 6, 2002, at 0:29:44

In reply to Re: AUGMENT PROZAC OR SWITCH SSRI » hiba, posted by freedom2001 on November 5, 2002, at 6:48:15

I am taking prozac for depression which was a consequence of severe obsessive rumination. So my diagnosis will probably be Obsessive depression, or depression with obsession. I began on 20 mg daily and it was helpful for sometimes. But gradually I lost the grip and had to double the dose.

I have tried pindolol at the initial stages and it definitely had an augmenting effect. The caution should be exercised when you switch to another drug, because the new drug shouldn't necessarily be as effective as the old one. Besides prozac takes a long time to have an effect and this duration could be much longer for the second time. It is my experience.
Tofranil, as a tricyclic will augment the effects of prozac but I don't think anafranil (clomipramine) is a good choice. Though a tricyclic, anafranil mainly targets serotonin and adding it to SSRIs will probably cause a serotonin syndrome. Prior to SSRIs Anafranil was the treatment of choice for OCD and still it is being hailed as the most effective OCD medication. But anti-cholinergic and sedative effects make its clinical indication lesser than SSRIs. If you are ready to bear those bothersom anti-cholinergic and sedative effects you can switch to anafranil with the consent of your treating physician. It is a highly effective OCD medication.
HIBA


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