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Dex/sleep - Modafinil(Provigil)- tyramine/dopamine

Posted by paulk on October 20, 2002, at 18:07:53

In reply to Re: Sounds like ADD, posted by Jo Ann on October 19, 2002, at 2:02:17

Sounds familiar – I’m guessing that during the time that D-amphetamine (Dexidrine) is in my system and releasing dopamine(DA) that it causes the general level of DA to increase. Then as the drug wears off – DA releasing neurons under-release due to partial depletion – causing the crash and sleepiness – as the night goes on the neurons regenerate DA stores and the background level of DA is still elevated enough to wake me up.

I had the problem at a low dose of only 7.5 Mg/day – Today is my first day at 15mg/day and I will see if my sleep is better or worse in the next week. Might be better sleep as the neurons will be more depleted.

Modafinil(Provigil) should only raise the background level of DA. I’m not sure that would give me the benefits in focus and prioritizing that I’m after.

I really want to do an experiment and take tyramine, it is tyrosine that is partly metabolized – I think almost to L-dopa. I find that I crave Cheddar cheese and would eat it all the time except for the high fat content. My hunch is that it acts as a pro-drug for DA (and probably NA also).


Jo Ann wrote on 10/19/02
> I take 20 mg of Dex per day, and for the last 3 or 4 weeks, I wake up halfway through the night, then fall back asleep about half an hour before my alarm goes off. This happened about a year ago when I first started the meds. I am going to the doctor on Monday to see what he thinks.



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