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Re: Lexapro Toprol interaction - there may be one » pharmrep

Posted by jane d on October 7, 2002, at 23:14:02

In reply to Re: drug to drug interactions/bottom » CarolinaGirl, posted by pharmrep on October 7, 2002, at 19:37:09

> > I have now been on lexapro for three weeks. (5mgs)
> > This dosage makes me drowsy. Tomorrow I go to see my doc and she will increase it to 10 mgs.
> > I am still going to sleep without taking ambien, so it is really helping the insomnia. I feel a little less anxious.....there is still room for improvement though. No nausea. This is the first
> > antidepressant I have been able take. I don't hate it! I do wonder about lexapro interacting with my toprol (for blood pressure). The doc didn't mention there could be an interaction. Found a website that mentioned it. Anybody here know anything about it....also mentioned that lexapro could lower your heart rate.
>
> ** no...your heart rate/blood pressure shouldn't change...no lexapro will not interact with your medications. The drug to drug interaction profile for lexapro is awesome...the p450 system has 0 interactions. Celexa is very mild in only 2 of the 5 major pathways in the liver, zoloft is mild to moderate in all of the pathways, and both paxil and prozac are moderate to severe in the p450 system (very likely to interact with other meds).

Pharmrep -
Are you aware that Lexapro's own prescribing information describes an interaction between Toprol and Lexapro? It may or may not be significant but I don't think it is appropriate for you to say or imply that it doesn't exist. I think you are misinterpreting the standard Lexapro advertising argument that it interacts with fewer other medications than do the other SSRI's to mean that it doesn't interact at all. That's a potentially dangerous misunderstanding.

Jane


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