Posted by chad_3 on September 22, 2002, at 16:33:50
In reply to Re: Questions Re: Parnate Nardil for social anxiety, posted by Dave001 on September 21, 2002, at 23:30:37
Dave -
> Well, we've had patients on high doses of amphetamines for over 50 years w/o apparent complications (treatment of narcolepsy). I think most of the studies linking neurotoxicity involved use of substituted amphetamines. And even then, it's the dose that makes the poison...
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The info I see seems to be often negative on Dexedrine for toxicity. Have not looked too much at this though ...
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> well to ultra low doses ; ie; 1.5mg lasts all day. However I only tried this a couple times
>
> That is ultra-low. I'm on 30 mg/day which is fairly typical. I have yet to experience any adverse interaction between Dexedrine and the Parnate.
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In my case the ultra low stims all tried with low for me (60) Nardil. Dexedrine toxicity is only thing concerning me here. I found that "rebound depression" the next day could be prevented with low Provigil pretty well.
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> Benzodiazepines are cognitive inhibitors though; they cause retrograde amnesia in high doses
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Klonopin is a pretty atypical benzo and also different types of people are effected differently. I would not compare it to Valium, no more than I would compare Prozac to Paxil in their effects on energy and sedation.
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> That's odd; a lot of psychopharmacologists have said the exact opposite: that is, Parnate works better for SP.
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Who? I never heard this from any psychiatrist. I would be happy to hear from anyone who takes Parnate in monotherapy for primary generalized SP to robust result. - http://www.socialfear.com/
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Sleep and weight gain. Nardil weight gain - I hear this is "classic" - but I don't quite know where that comes from. Tricylics, Paxil,
> Err, the perhaps the literature? Just a guess. ;-)
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I can't go too long here - but Nardil is old and the newer drugs - the ones most used are worse overall IMO. Low and medium dose Nardil is unlikely to be a problem with weight gain or sedation. At high doses some people will get these effects to some degree - true with most psychotropics - most antidepressants currently out will tend to cause weight gain and sedation even at medium or low dose levels ... paxil, zoloft, celexa, luvox, remeron, serzone, ... tricyclics (rarely used due mainly to side effect problems)... etc...
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> You say, "fading to axiogenic." [sic] What do you mean? You felt an amphetamine-like effect with subsequent anxiety *after* the effect?
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yes with many of the dopaminergics ... ritalin definitely, parnate, amineptine. What is unique IMO about dexedrine is it's relatively significant serotnergic agonist effect gives can give it a lasting non-axiogenic antidepressant effect in addition to the dopaminergic and stimulant effect.
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> > Parnate I kind of liked the middle dose range - saw no advantage to higher - all were tolerable except for not working for me.
>
> Why did you like the middle-range dose if it didn't work for you? :-)
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I should rephrase - it was effective as a simulating, non-axiolytic antidepressant. I described previossly that the axiogenic effect resulted in poor results in helping my SP - I was agitated and uninterested in socializing with people.Chad
http://www.socialfear.com/
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poster:chad_3
thread:120640
URL: http://www.dr-bob.org/babble/20020922/msgs/120761.html