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SSRI's have a flat dose-response curve » hawkeye

Posted by Ritch on September 22, 2002, at 11:07:14

In reply to Re: why/see bottom, posted by hawkeye on September 22, 2002, at 7:05:02

> ".why are you wanting to use less?"
>
> Because at 10 mgs I was having unacceptable sexual side effects. Because the drug is working so well for my depression I am trying to find a way to keep with it.
>
> One additional thought, You say that at 5mg the onset of the anti-depressant effect is slower than at 10mg. Perhaps the way to go for those who are known to be sensitive to this drug from their experience with Celexa would be to start at 10mgs to get a rapid antidepressant response and then cut back to 5mg to reduce the side effects.
>
> Bummer for me that I am having these side effects at 10mgs/day. For me the side effects at 10 mgs of Lexapro are as severe as they were at 40mgs of Celexa.


Hawkeye,

When I was started on Celexa for the first time a few years ago-when it was available in the US for the first time-I started at 10mg (half a 20mg tab) first off. I felt better, had some side effects, but they weren't real bad. Then later on as my depression worsened (mid-winter bpII seasonal), my pdoc had me up it to 20mg. I felt a *little* better, but my side effects got a lot worse, so I backed down to 10mg and added some Wellbutrin (which did the trick). Anyhow, over about 3 years of being on and off Celexa (most on-and with other AD's,etc.), I found that 5mg and 10mg of Celexa felt pretty much the same (but with 5mg being much more tolerable). Even 2.5 didn't feel much different than 5.0mg. So, in my experience, the range of 2.5-10mg felt little different except for s/e. I think they need to put a score on those 5mg tabs of Lexapro. If they do, I might give Lexapro a try. Even scored *2.5mg* tabs would be neat (esp. for those that take other meds with it).

Mitch


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URL: http://www.dr-bob.org/babble/20020922/msgs/120729.html