Posted by sleepy lizard on September 11, 2002, at 15:17:34
In reply to Effexor and excessive.. well..., posted by TenelKa on September 7, 2002, at 19:04:30
There is definately a time delay on the sexual side effects of the various drugs that have and effect on seretonin and other neurotransmitters (from my experiance with Paxil, Celexa, Effexor XR, Wellbutrin SR). Also the different drugs work with different receptors which have specific effects. Notice in the following list that 5HT2 and Alpha-2 NE have the most effect on sexual functioning.
Two of the side effects of Effexor that I have seen listed are increased libido and anorgasmia. I have experienced the anorgasmia and also erectile dysfunction on Effexor XR. I can't say that Effexor XR increased my libido, because it was already maxed out (I am always interested). Just one the side effects of being Male with testosterone I guess. People with high sex drives have to learn to moderate those feelings, usually I exercise and do intellectual things to use some of the energy.
Dr. Sheldon Preskorn has some interesting information on his site: http://www.preskorn.com
Table 4. Sites of Action and Clinical and Physiological Consequences of Their Blockade or Antagonism
Site of Action Consequences of Blockade
Histamine-1 receptor = Sedation, antipruritic effect
Muscarinic acetylcholine receptor = Dry mouth, constipation, sinus tachycardia, memory impairment
Norepinephrine (NE) uptake pump = Antidepressant efficacy, increased blood pressure, tremors, diaphoresis
Serotonin (5HT2) uptake pump = Antidepressant efficacy, nausea, loose stools, insomnia, anorgasmia
5-HT2A receptor = Antidepressant efficacy, increased REM sleep, anti-anxiety efficacy, anti-EPS
Alpha-1 NE receptor = Orthostatic hypotension, sedation
5-HT2C receptor = Anti-anxiety efficacy, increased appetite, decreased motor restlessness
5-HT3C receptor Antinauseant
Alpha-2 NE receptor = Antidepressant efficacy, arousal, increased libido
Sodium fast channels = Delayed repolarization leading to arrhythmias, seizures, delirium
poster:sleepy lizard
thread:119232
URL: http://www.dr-bob.org/babble/20020906/msgs/119556.html