Posted by Shawn. T. on August 4, 2002, at 1:38:41
In reply to Re: Tianeptine: Effective Tolerable Antidepressant, posted by cybercafe on August 3, 2002, at 5:43:38
> Oops i made a mistake... it seems fluoxetine may work by increasing the sensitivity (expression) of D2 receptors in the nucleus accumbens, not by increasing the level of dopamine
>
I agree that fluoxetine can increase the expression of D2 receptors in the nucleus accumbens, but it probably has that effect only in higher doses. An increase in D2 receptor mRNA in the nucleus accumbens would be an undesirable effect in my opinion.> > Fluoxetine (Prozac):
> > "In conclusion, the 5-HT-induced facilitation of NAc DA neurotransmission described in the literature may not be relevant to the therapeutic action of fluoxetine(3)."
>
> interesting... why is it not relevant? ...
>
>
I believe that they are implying that the literature in question is incorrect. I'll try to figure out the alleged literature in question some time to figure out why they may have made a mistake. I have a feeling that the reason why some people taking SSRI's cannot experience normal "highs" has something to do with the VTA-nucleus accumbens pathway, but that is just speculation (I don't feel like try to prove it in other words). Check out the following link for lots of free full text (not just the abstract) pharmacological reviews. The second link has a lot of information about D3 receptors; you should find it interesting.http://pharmrev.aspetjournals.org/cgi/search?qbe=pharmrev;54/2/161&journalcode=pharmrev&minscore=50
Shawn
poster:Shawn. T.
thread:114758
URL: http://www.dr-bob.org/babble/20020731/msgs/115115.html