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Re: Switching from Zoloft to Wellbutrin » Preston

Posted by Sunnely on July 27, 2002, at 23:30:40

In reply to Switching from Zoloft to Wellbutrin, posted by Preston on July 27, 2002, at 16:09:38

Wellbutrin does not have serotonergic effect so taper down Zoloft very slowly to avoid withdrawal symptoms. You may add Wellbutrin SR first then titrate upward to therapeutic dose (e.g., 150 mg daily for 1 week then increase to 150 mg twice daily; may go as high as 450 mg daily). Then taper down Zoloft slowly to avoid withdrawal symptoms (e.g., cut down by 25 mg weekly instead of 50 mg). You can also combine the two for better antidepressant effect.


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