Posted by oracle on July 8, 2002, at 23:30:28
In reply to ELECTRIC SHOCK SENSATIONS*** what is occurring, posted by geno on July 6, 2002, at 19:52:14
Shocks, hmmm, lets ask the monograph:
In man, following oral once-daily dosing over the range of 50 to 200 mg for
14 days, mean peak plasma concentrations (Cmax) of sertraline occurred between 4.5 to 8.4 hours
post-dosing. The average terminal elimination half-life of plasma sertraline is about 26 hours. Based on
this pharmacokinetic parameter, steady-state sertraline plasma levels should be achieved after
approximately one week of once-daily dosing. Linear dose-proportional pharmacokinetics were
demonstrated in a single dose study in which the Cmax and area under the plasma concentration time
curve (AUC) of sertraline were proportional to dose over a range of 50 to 200 mg.
N-desmethylsertraline to be substantially less active than sertraline. Both sertraline and
N-desmethylsertraline undergo oxidative deamination and subsequent reduction, hydroxylation, and
glucuronide conjugation. In a study of radiolabeled sertraline involving two healthy male subjects,
sertraline accounted for less than 5% of the plasma radioactivity. About 40-45% of the administered
radioactivity was recovered in urine in 9 days. Unchanged sertraline was not detectable in the urine. For
the same period, about 40-45% of the administered radioactivity was accounted for in feces, including
12-14% unchanged sertraline.
<end monograph>(Oracle note: "oxidative deamination and subsequent reduction, hydroxylation, and
glucuronide conjugation" Try doing that in the lab some time ! The liver does it with no sweat.)So as AD's go ZOLOFT(sertraline) hangs around for days, unlike many other
AD's (like Prozac) that take weeks to clear. Effexor is even faster
acting, it clears in hours. Effexor is well known
for the shocks, more so than any other AD. The length of action is
in direct relation to the discontinuance effects.Taper, taper, taper. As long as it takes. If you start having problems
you are tapering too fast. I take Effexor and get the shocks if I forget a dose.
I am used to them. Atavin stops them dead. Since the shocks last at best a day
with me, Atavin is my choice.Many seem to think that mental illness is about
a lack of NT's. It does not work this way. It is really about
regulation of these NT's. AD's, after all, regulate
the amount of NT kept around (at the gap), before the MAO
process happens (NT's are deactivated). This is why
supplements of the building blocks for NT's don't work.
The body indicates this as if you take in excess precursors
that are passed, unused. the building blocks are the aminos,
they are very abundant in all foods.So if one stops cold from the shorter acting AD's
it is a given that there will be problems. If one did taper
and is still having problems, a slower taper is indicated.
As slow as it takes to keep the problems at bay.One dose of Prozac can end all this (shocks,ect)as it will
slowly leave you body over a month. A very slow and even taper.
Withdrawal methods are mentioned here:
http://groups.yahoo.com/group/psycho-babble-tips/links/Effexor_and_Effexor__000963295972/
What works for Effexor is worth considering for ZOLOFT.
Cam is a poster who is not here now. He is a pharmacist
with special interests in psyco meds. He also has mental illness,
and was treated with Effexor. Well worth reading.
You can read what he has said (2000-2001) here:
http://www.dr-bob.org/cgi-bin/xv/search.plUse this format, match all terms
poster:Cam shocks zoloftHe posted over 300 times about Effexor and shocks,
so take a look at those also.Short answer: AD's that are allowed to leave the body too
quickly shock your nervous system. It took a month for the meds
to regulate your neurology so it is only fair to take whatever time is needed
to slowly let things readjust. If not, expect problems.Happy hunting !
If you find something you want to try, do ask
your doc first.
poster:oracle
thread:111602
URL: http://www.dr-bob.org/babble/20020628/msgs/111815.html