Posted by BLPBart on July 7, 2002, at 15:04:52
In reply to Re: Balked shmalked -BLPBart, posted by BekkaH on July 6, 2002, at 20:20:12
> I'm now having some strange side effects just showing up and I'm afraid it's the wellbutrin. I've been reading a lot lately about wb having interactions with other medications, including amphetamines. I'm thinking about just staying on the dex and see if it helps with the depression as well as the ADD.
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> Hi. May I ask what strange side effects you are having on the Wellbutrin plus dexedrine combo? Wellbutrin and/or at least one of its metabolites suppresses the liver enzyme known as cytochrome P450 IID6. Dexedrine is a substrate for that enzyme (i.e., it needs the enzyme in order to be metabolized). If the enzyme is suppressed too much, then dexedrine won't be properly metabolized and could build up to dangerous levels in some people.
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> Some people (5-10% of Caucasians, as well as some others) have genetic polymorphisms for this enzyme, and it may not function as well as it does in those who don't have the genetic polymorphism. I know some people who do very well on that Wellbutrin + Dexedrine combination. I know others who do well on Wellbutrin + Ritalin; unfortunately, I am not one of them. I am quite certain I lack the IID6 enzyme, or else I have a "deficient" version of it. When I tried the Wellbutrin + stimulant combinations, I got quite sick, but you may not have the same problems I have. Perhaps something else is causing those strange side effects. Did you change your dosage recently?
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> BekkaHi Bekka,
I'm about 99% convinced that the interaction with drug metabolism is what caused me to have the problems when I combined prozac with wellbutrin.The problems I'm having now are completely different. About a month ago I started having extreme post-nasal drip which makes me feel like I constantly have to swallow. Then to make matters worse, I sometimes feel like I can't swallow (very hard to describe). It's like I have to concentrate really hard on the muscles that I need to swallow. I tried adding antihistamines and decongestants. These do nothing for the post-nasal drip, just add to the problem with dry mouth that I already have from the dex/wellbutrin combo. I've been doing some research and found out that rhinitis is a fairly common side effect from wb although I don't know why it would suddenly start now. I'm wondering if I'm already having some problems because it's allergy season and the wb is just making it worse. I'm afraid this might sound trivial to my pdoc but it's really driving me nuts. My throat hurts, I feel like I'm drowning in my own snot (sorry, I know that's gross) and I'm always sick to my stomach because of it.
poster:BLPBart
thread:111452
URL: http://www.dr-bob.org/babble/20020628/msgs/111683.html