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Re: Memantine / Amantadine

Posted by JohnX2 on June 1, 2002, at 20:23:52

In reply to Memantine / Amantadine, posted by Seamus2 on June 1, 2002, at 9:28:01

> Hi Scott,
> Have you done a Medline on amantadine for the same use? I think they are chemical cousins and iirc, amantadine is a DA agonist.
> Seamus

The two medicines are are almost molecularly identical.
Memantine has 2 extra CH3 groups.

I don't know how the physiological properties compare.
Are they apples-to-apples?

The molecular weight of memantine is greater than
amantadine. But the therapeutic dose for memantine
off the top of my head is around around 30mg and
amantadine is 200-400 mg. Supposedly amantadine is
much more intolerable.





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