Posted by 3 Beer Effect on May 31, 2002, at 13:51:10
In reply to Can you take Ritalin w/ Dexedrine?, posted by Jerrympls on May 30, 2002, at 23:52:42
I wish I owned or started my own pharmaceutical company since I have so many ideas on how to improve the somewhat dissapointing array of psychiatric medications available out there.
Doctors never prescribe Ritalin & Dex/Adderall together, it is never even mentioned as a possibility in medical literature. Also this combo is never prescribed because these are Schedule II medications tracked/recorded by the DEA & a prescription for two Schedule II ADD drugs to the same person looks suspicious, & also perhaps because the combination might cause an unpredictable rise in blood pressure- in other words the doctor is afraid of liability/malpractice & the DEA.
But, since they act by different mechanisms, if you combined one of the amphetamines- either Dexedrine/Dextrostat or Adderall- AND/WITH RITALIN, taking into account their time to peak blood level (tmax) & duration of action the Dex or Adderall + Ritalin combo would create a "super double whammy" affect on dopamine potentiation!
The reason is that in low to normal dosages the amphetamines Dexedrine/Dextrostat & Adderall primarily RELEASE newly stored/synthesized Dopamine & Norepinphrine into the neuronal space. Ritalin on the other hand, is a dopamine & norepinephrine REUPUTAKE BLOCKER, & fairly similar in its actions to Cocaine (devoid of local anasthetic activity) but superior in that it is much longer lasting, less reinforcing, & is "remarkably non-toxic."
When dopamine & norepinephrine are subject to 'reuputake' into nerve terminals, they are both are destroyed or inactivated by the 'janitorial' enzymes MAO, COM-T, & even the process of reuputake itself.
So if you add Dex & Ritalin together, it is not 1 + 1= 2 but a more potent dopaminergic combination.
Note: if the above explanation is confusing, here is a simple analogy. Imagine you are looking at a reservoir with a dam at the bottom and a stream up top.
Dex/Adderall cause the dopamine/norepinphrine 'stream' to flood, filling the reservoir (the neuronal space) with more 'active' dopamine & norepinephrine.
Ritalin & Cocaine lock all the dam overflow gates & fortify the dam preventing any 'active' "reservoir water" (=dopamine & norepinephrine) from escaping/overflowing the reservoir. When the Ritalin or Cocaine wear off, excess or aged dopamine or norepinephrine escape the resevoir & are killed downstream by evil knife wielding gang-member bandits of the notorious MAO or COMT krews.
The city council might step in & say its time to rid our streets of these evil gangs MAO & COMT.
To do that they bring in one of the big bad super cop anti-gang units called "Parnate, Nardil, or Selegeline/L-Deprenyl". These three anti-gang units wipe out the MAO & COMT gangs quick but then the norepinephrine & dopamine blocks of the city go 'wild in the streets' on their dangerously potentiated Dex/Adderall/Ritalin & form a truce in order to create a bigger, badder, more lethal gang called "hypertension" that attacks the heart of the City causing the power to go out (for good).
3 Beers...........
poster:3 Beer Effect
thread:108121
URL: http://www.dr-bob.org/babble/20020525/msgs/108207.html