Posted by 3 Beer Effect on May 13, 2002, at 23:26:34
In reply to Re: No! potentially fatal combination! » 3 Beer Effect, posted by JonW on May 13, 2002, at 8:46:57
DRUG INTERACTIONS: "Selegiline (L-Deprenyl) can cause hypertensive crisis (fatalaties reported)--do not administer amphetamines during or within 14 days of these drugs."
Actually, I found the info in a book, I don't think its on the internet. The warning seems to apply to all U.S. available MAOIs ("these drugs") but it does specifically mention fatalaties reported with Selegiline & Amphetamines. Additionally, under the Selegiline Hydrochloride section it says "DRUG INTERACTIONS: same as with other MAO inhibitors, including severe reactions with Meperidine. Fluoxetine & possibly Sertraline & paroxetine, increase risk of CNS toxicity & muscle rigidity. TRICYCLIC ANTIDEPRESSANTS can cause severe CNS toxicity."
The book is the excellent quick reference drug book Prentice Hall "Nurse's Drug Guide 2002." That passage is under the dextroamphetamine sulfate, drug interaction section.
"Amphetamines" applies to Dextroamphetamine Sulfate-Dexedrine, Dextrostat;
Mixed salts of amphetamine- Adderall, & D-Amphetamine Combo (Barr-generic Adderall);
& Desoxyn (methamphetamine hcl) & to many of the amphetamine-related anorectics such as Didrex (Benzphetamine) & Sanorex (mazindol).The various forms of methyphenidate (Ritalin, Concerta etc) are also contraindicated with MAO inhibitors including Selegiline.
No one except Parkinson's disease patients should even be taking Selegiline/L-Deprenyl. It's a shame it is so widely available on the internet & is marketed as l-deprenyl by overseas "pharmacies" that lie & omit facts about how dangerous this drug can be. Even otc cold, asthma, or herbal weight loss medicines that contain ephedrine, ephedra, or pseudoephedrine could easily cause a hypertensive crisis with Selegiline/L-Deprenyl.
3 Beers..........
poster:3 Beer Effect
thread:106127
URL: http://www.dr-bob.org/babble/20020510/msgs/106267.html