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Re: Your provigil jitters SLS

Posted by Iago Camboa on May 13, 2002, at 12:55:00

In reply to Re: Your provigil jitters, posted by SLS on May 11, 2002, at 7:00:06


The more I read about the varied reactions to Provigil and the more I'm convinced that the two drugs, namely adrafinil and modafinil/Provigil are completely different drugs. Who would have guessed so after having looked at their formulae (only differing by a 'trifling' OH)? Worse still, the latter being a metabolite of the former...

So your reasoning seems to me both very sound and one worthy of further inquiry... And I'm afraid I will only take rest after I will have tried that substance (modafinil/Provigil) on myself...


> If you look back a year or so, you will find posts regarding adrafinil by JohnL, who is doing extremely well with it. At one point, he tried crossing over to modafinil (Provigil) - twice. Both times, he immediately experienced uncomfortable anxiety, spaciness, and jitters along with a persistant headache. I don't recall at what dosage he started Provigil, so I guess it can't be excluded that his experience was due to his taking too much. He probably started at 200mg. He characterized the two drugs as feeling completely different.
> Adrafinil is converted to modafinil in the body, but I am not sure to what extent. If the percentage is small enough, perhaps the steady-state levels of modafinil in the body equate to a dosage of something like 50mg. I really don't know, but if this is the case, I imagine it's possible that adrafinil is doing most of the good stuff while leaving too little modafinil to do the negative stuff. Again, it is possible that he started modafinil at too high a dosage.
> - Scott




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