Re: Hey folks: Look what I found re Depakote/GABA!! » Janelle

Posted by SLS on May 8, 2002, at 17:08:07

In reply to Hey folks: Look what I found re Depakote/GABA!!, posted by Janelle on May 7, 2002, at 17:44:12

Hi Janelle.
> Based on this, somehow (not sure just how) Depakote does something to enhance the presence of GABA in the brain!
Depakote (valproate) increases the amount of GABA available by inhibiting an enzyme known as GABA transaminase. This mechanism is analogous to how MAO-inhibitors work to increase the levels of the monoamines (DA, NE, 5-HT). Two other drugs I know of inhibit GABA transaminase: the MAOI Nardil (phenelzine) and the anticonvulsant Sabril (vigabatrin).
Depakote also acts to stabilize nerve cell membranes by slowing-down the movement of ions (electrically charged molecules) through sodium channels.

- Scott

Thread

What about Klonopin, Depakote and GABA... Janelle 5/6/02
...
Mitch, update here! » Ritch Janelle 5/7/02
Re: Mitch, update here! » Janelle Ritch 5/7/02
Janelle! Update here! :-0 » Ritch Ritch 5/7/02
benzodiazepine mechanism katekite 5/7/02
Mitch: thanks for article link - GREAT article! (nm) » Ritch Janelle 5/7/02
KATEKITE: fantastic explanation! Thanks SO much (nm) » katekite Janelle 5/7/02
Hey folks: Look what I found re Depakote/GABA!! Janelle 5/7/02
Here's something right on Klono vs. Depa and GABA! Janelle 5/7/02
Re: Here's something right on Klono vs. Depa and GABA! djmmm 5/7/02
Wow, even more info, thanks a lot! (nm) » djmmm Janelle 5/7/02
Re: What about Klonopin, Depakote and GABA... » Janelle JohnX2 5/8/02
John, great GABA link. Thanks for posting it. (nm) » JohnX2 Ron Hill 5/8/02
Re: Hey folks: Look what I found re Depakote/GABA!! » Janelle SLS 5/8/02
Re: Hey folks: Look what I found re Depakote/GABA!! SLS 5/8/02
Neato compilation..bookmarked it! thanks (nm) Ritch 5/8/02
Re: Nice table Scott » SLS Ron Hill 5/9/02
Re: Nice table Scott » Ron Hill SLS 5/9/02
Re: Nice table Scott petters 5/9/02
Looking good, Scott » SLS lizzyg 5/9/02
Re: Nice table Scott » petters SLS 5/9/02
Re: Here's something right on Klono vs. Depa and GABA! geno 5/9/02
Re: Looking good, Scott » lizzyg SLS 5/10/02
Re: Looking good, Scott » SLS lizzyg 5/17/02
Re: Looking good, Scott SLS 5/26/02
Re: Looking good, Scott -- Looking Great! (nm) Seamus2 5/27/02
...
Re: Where is Mirapex? » Denise528 SLS 5/28/02

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