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Re: LAMICTAL usage for soft Bipolarity, (((SLS))) » petters

Posted by SLS on April 11, 2002, at 17:15:20

In reply to Re: LAMICTAL usage for soft Bipolarity, (((SLS))), posted by petters on April 11, 2002, at 12:33:27

> I am going to increase Lamictal from 100 mg to 200 mg. Do you think I can do it a bit qicker than 25 mg every second week? What about raise from 100 mg to 150 mg today, and than 2 week at this dosage, and after that increase the dosage to 200 mg?

You should be able to increase Lamictal quickly. JTo be safe, you can increase the dosage to 150mg for 7 days, and then to 200mg.

> As you know I suffer from Bipolar II + ADD. Is Effexor as effective like Zyban regarding ADD??

I don’t know that much about ADD. I do know that there is a statistical association of comorbitity of the two. What are your symptoms of ADD?

ADD and AD/HD have two components:

1. attentional
2. behavioral and motivational

The attentional component is treatable with psychostimulants. The behavioral / motivational are the components that antidepressants can help. I knew someone (adult) who responded well to imipramine. I think Parnate helps with both.

If you hava already tried methylphenidate and amphetamine, perhaps you can try pemoline (Cylert). In addition to improving attentional deficits, it can be an effective augmentor of antidepressants. It increases dopaminergic tone in a way that is different from the other psychostimulants. I believe it promotes the passive release of DA from presynaptic neurons. I had a doctor that liked to combine it with Parnate for depression.

A few open trials in the US reported that Effexor was effective for ADD. Other trials have reported the bupropion was effective too. No double-blind studies. The investigators of the venlafaxine study I read a few years ago liked venlafaxine more than bupropion.


- Scott

 

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