Posted by Elizabeth on April 4, 2002, at 22:46:48
In reply to That is incorrect Dr. Kramer, posted by Tye on April 2, 2002, at 20:41:31
> At dose above 300 mg, venlafaxine acquires dopamineric activity. It still retains serotonin and norepinephrine qualities at this dose range, and does *not* become mostly noradrenergic. If the medication did become mostly noradrenergic, the serotonergic benefits/side effect would dissipate.
Not necessarily. I'm not sure what Dr. Kramer meant, but it could equally mean that the NE effect continues increasing while the 5-HT effect plateaus, so that the NE effect dominates at higher doses. It could even just mean that the rate at which the NE effect increases surpasses the rate of increase of 5-HT effects. It certainly doesn't imply that the 5-HT effect *decreases* as the dose increases -- just that it decreases *relative* to the NE effect.
BTW -- are you sure that 300 mg/day is about where the DA effect starts kicking in? I had been looking for that info, and I wasn't able to find out the answer. Can I ask where you found that out?
-elizabeth
poster:Elizabeth
thread:101450
URL: http://www.dr-bob.org/babble/20020402/msgs/101894.html