Posted by shelliR on March 28, 2002, at 13:22:56
In reply to Re: buprenorphine for chronic pain? » shelliR, posted by Elizabeth on March 26, 2002, at 21:13:55
Hi Elizabeth,
I am still taking bupe; I keep needing to go up, though. I am going to try to get it from my present pdoc, if he won't then I'll continue looking. Right now I am still titrating up on lamictal, up to 350mg now; am willing to go to 800 if necessary. (Dr. Goldberg mentions this as ceiling dose, anyway.) After that I am thinking about re-trying effexor. First time I threw up, but I can keep trying crumbs, I suppose, until I get used to it. How long til you felt the positive effects of effexor? Do you think that effexor is the most potent AD besides the MAOIs?
> Was the maximum effect the same with the same dose taken by the two different routes?You tell me: "Bruprenorphine is well absorbed in man by the sublingual route, giving plama levels at 2-3 hours after administration which are comparable to those observed at the same time following a similar dose given by the parenteral route. After parenteral administration, plasma concentrations decline in a triexpontial manner, indicating a terminal half-life of about 5 hours. For sublingually administered buprenorphine, peak plasma levels were achieved with 200 minutes, with a systemic absorption half-life of 76 minutes."
can you explain that to me in English?
> > BTW, I did try inhaling it this morning ....
Actually for me it does burn, so I stopped.
> Heh. Get used to it! (At least you don't have to go into a pharmacy. Those guys make you feel like a junkie just for having a prescription for Ambien or something. :-) )
Actually, my pharmacy was not alarmed in any way by the oxycontin, so I suppose buprenorphine won't be a big deal.
> > > I think you're right that your previous use of methadone and oxycodone may have had a lasting effect on your tolerance.I wish so much that I had taken buprenorphine instead of oxycontin to start.
I can manage for a couple days with just the Effexor (tried it recently), but my energy is low and my thoughts aren't very clear. I definitely couldn't function adequately without buprenorphine.
I would be in horrible shape. I have a few hydrocodone but not much. I'm wondering if now that I'm up to 350 on lamictal, when I can start titrating faster. I might ask dr. goldberg in an e-mail. Btw, did you ever contact a Donald Klein, at New York State Psychiatric Institute in NYC? His name has been given to me by several pdocs who would not take me on.
> Sure, if he did something wrong (like that other guy you were seeing) then he'd be open to a lawsuit. Do you think he would do something wrong, though?I don't know what it means to do something wrong, except to let me go off cold turkey. And I don't think he's as pompous as the last guy. Of course, I don't think anyone's as pompous as the that pdoc.
>
> > I don't want to go off it now; I'm just starting to catch up on work and I don't want to go to the land of living hell again.
>
> That's entirely understandable! Doesn't it feel amazing to come out of it, though? Several people I know (including my parents) have said that I came "back to life" when I started taking it.On .6mg twice a day now, I am only half-way into "back to life" At first, with a way lower dose, I was fully here. I am quite discouraged.
I'm glad that your depressive days seem to be over.
Shelli
poster:shelliR
thread:97162
URL: http://www.dr-bob.org/babble/20020327/msgs/100765.html