Posted by JonW on March 24, 2002, at 22:16:03
In reply to Moclobemide/Kava Kava combination?, posted by Will_Hung on March 24, 2002, at 20:24:11
Hi Will,
I'm sorry you've suffered with such a horrible disorder. As far as I know, Kava is an MAO B inhibitor. I know that if *selegiline* (an MAO B inhibitor) is combined with moclobemide, dietary restrictions are necessary. That being said, I'd be hesitant to ignore the restrictions when using Kava. You may want to try klonopin or another benzo instead. How long have you been on moclobemide? It's my understanding that a fair trial for social phobia is no less than 12 weeeks at doses up to 1600mg if tolerated. Easier said than done, I know.
Good Luck,
Jonp.s. Here the titles of some relevant abstracts:
Uebelhack R, Franke L, Schewe HJ. Related Articles
Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava).
Pharmacopsychiatry. 1998 Sep;31(5):187-92.
PMID: 9832350 [PubMed - indexed for MEDLINE]Korn A, Wagner B, Moritz E, Dingemanse J. Related Articles
Tyramine pressor sensitivity in healthy subjects during combined treatment with moclobemide and selegiline.
Eur J Clin Pharmacol. 1996;49(4):273-8.
PMID: 8857072 [PubMed - indexed for MEDLINE]> Evening All.
>
> I am a twenty-something blessed with social phobia and/or borderline AvPD.
>
> I have been taking Moclobemide at a dosage of 750mg/day for some time now, which seemes to help a liitle. However, I am keen to try Kava Kava (a herbal supplement) which is reputed to relax and enhance 'social performance'.
>
> Does anybody know of any risks in using the two concurrently?
> Has anybody actually tried both at the same time?
>
> I really need to know if Kava has any effect on MAOI-B levels, as I am not currently following a MAOI diet, and I do not wish to.
>
> If anyone can point me in the direction of studies on the actions of Kava Kava in the body it would be much appreciated (I'm sure there will have been some).
>
> Thankya kindly
> Will
poster:JonW
thread:99946
URL: http://www.dr-bob.org/babble/20020322/msgs/99958.html