Posted by BarbaraCat on March 27, 2002, at 1:25:47
In reply to Re: BY GEORGE, have I got it??!!?? » Janelle, posted by Mr.Scott on March 26, 2002, at 22:18:31
Just want to clarify here. The two neurotransmitters most implicated in depression are serotonin and norepinephrine and there are different SEPARATE neuron types residing in different parts of the brain that 'specialize' in their respective neurotransmitters. There are a few reuptake pumps on the axonal terminal ends that recycle the serotonin, norepinephrine, dopamine, or whatever transmitter that neuron specializes in. However, there is not a separate pump for each neurotransmitter that is floating in the synaptic cleft. Things would get very crowded in there. Each reuptake pump can recycle boatloads of the transmitters back into the axonal vesicles. I'm not sure if this was what Janelle was asking or not, but wanted to highlight the fact of separate neurons handling separate classes of neurotransmitters, each with far fewer pumps than neurotransmitter molecules. - BCat
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> Every serotonergic synapse in the brain has a serotonin reuptake pump. Each of these clean drugs affect a lot more than that though even though they are called clean drugs, they aren't. Each having different affects at different receptors and a whole chain of consequences both inside the cell and along the neuronal pathways and the pathways that those pathways are connected to and so on.
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> Try this link
> http://www.preskorn.com/columns/0005.html
>
> Scott
poster:BarbaraCat
thread:100140
URL: http://www.dr-bob.org/babble/20020322/msgs/100482.html