Posted by SLS on March 15, 2002, at 7:04:36
In reply to Re: The inside poop on GEODON dosage.))) SLS, posted by petters on March 14, 2002, at 2:23:08
Hi Petters.
> So nice to see you are back. I really hope that you not feeling to badly for the moment.
I received your email. I’m sorry that I haven't responded to it yet. I have felt a little better the past few days, so I'll write to you soon.
> Have you make an trial on citalopram yet?
I haven't tried it yet. I must first try combining imipramine + venlafaxine. It is logical, although I am not expecting miracles. I spent too much time with nortriptyline + venlafaxine. Nortriptyline produced episodic improvements, but no single dosage worked for more than a few days. 75mg is too low and 100mg is two high. There is no therapeutic window for me. My doctor claims that this is the case in as much as 20% of people. That is a huge number. I have never seen any published statistics regarding this.
> I am a bit depressed for the moment. You know it is spring now in my country, and my depression always get worser in these period of time.
Have you ever tried light therapy? Some people with seasonal affective disorder (SAD) exhibit a cycle that is reversed from the typical case.
> I have replaced the mirtazapin, with nefazodene because of the side effect. Nefazedon was great in the beginning, but pooped out after a week or two. I know you also have this problem, with severel meds.
Can you get memantine from Germany? Some people on Psycho-Babble think that memantine might help prevent antidepressant poop-out (tachyphylaxis). Like amantadine, it works to modulate NMDA receptors. It also has neuroprotective properties.
> Nefazodone cause cognetive disturbance. Especially memory disturbance. Not so good for sleeping as Remeron. I have to take propiomazin as an add on to nefazodone. Not so good for sexual side effect as Remeron. Especially desire.
> Any thoughts of replacing Serzone with?
I forget what drugs you have tried. Do you want to block 5-HT2a receptors? The atypical neuroleptics (aripiprazole, risperidone, olanzapine, ziprasidone) are potent antagonists at these receptors. They might be worth trying at low dosages.
Atypical Neuroleptic Binding Profiles:
http://sl.schofield3.home.att.net/medicine/aripiprazole_binding.pdf
Also, there is a drug named ritanserin that is a very selective "clean" 5-HT2a antagonist that has remained experimental for a long time. Maybe it is available in Europe or Japan. I don't know. I doubt it, though. Eastern (Sufrexal, Aseranox, Ketensin, Ketanserina, Perketan, Serepress) is also a 5-HT2a antagonist, but it has more side effects. It is available in Europe and it is used to treat hypertension.
> mirtazapin:
> The main reason for stop it was reccurent infections. I had approximately 4 infections per year. Sore throat, Sinut etc despit normal bloodcells. Cortisol level up?? Hypotesis. I don’t think it is the venafaxin, because i had it as a mono terapi for one year without this pattern
When I first began taking Lamictal, I experienced a persistent sore throat. Blood tests, throat culture, and endoscopic examination were all negative. It lasted for about six months, then it disappeared. I haven't had any recurrences over the last 4 or 5 years. Lamictal continues to produce dandruff (flaking dry scalp) and patches of dry, red scabbing skin on my face. Shampoos containing zinc pyrithione prevent the dandruff and moisturizing skin creams help with the facial dryness.
> It? a crual joke with this poop out.
YES.
> I definitely think I'm a rapid metabolizer, because I tolerated high dosage.
>
> My current mix:
> T. Litium
> T. Lamictal 100 mg
> T. Effexor 300 mg
> T. Serzone 400 mgI must take 300mg of Lamictal. When I try to reduce the dosage to 200mg., I lose the small benefit it gives me. (It only helps me when I take a tricyclic at the same time).
How much lithium are you taking? I am thinking about taking 300mg. I think it exerts neuroprotective and neurotrophic effects at this low dosage. Maybe it preserves or enhances neuroplasticity. I don't know.
Take care, Petters.
- Scott
poster:SLS
thread:97468
URL: http://www.dr-bob.org/babble/20020313/msgs/98120.html