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JOHNX2 - question about your info here: » JohnX2

Posted by Janelle on March 15, 2002, at 0:28:22

In reply to Re: Is Serzone an SSRI? If not what is it?! Thanks » Janelle, posted by JohnX2 on March 14, 2002, at 22:41:40

Is blocking the reuptake of something (let's say serotonin) the same thing as blocking a particular receptor (say 5ht-2a)? I'm getting confused because ...

You said that Serzone is a mild serotonin reuptake inhibitor, a concept I'm familar with.

You also said that Serzone blocks, i.e. gets in the way of serotonin activating, a particular serotonin receptor (5ht-2a) that people think is linked to anxiety and depression.

And you said that most atypical anti-psychotics like Zyprexa also do the same thing (block this receptor), that Serzone also blocks the reuptake of noradrenaline (norepinephrine) and that Serzone mildly blocks a particular norepinephrine receptor as a side effect (the alpha-1), which may lead to a bit of fatigue for some people but for many people the norepinpherine reuptake inhibiting property offsets this, so no side effect.

I'm not quite getting the difference between blocking the reuptake of a neurotransmitter (like Serotonin) and blocking an actual receptor - could you explain the difference if there is one? Thanks!
-Janelle


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poster:Janelle thread:98014
URL: http://www.dr-bob.org/babble/20020313/msgs/98077.html