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Re: why can't they make a parnate/nardil patch? » christophrejmc

Posted by Elizabeth on February 28, 2002, at 16:37:17

In reply to Re: why can't they make a parnate/nardil patch? » JohnX2, posted by christophrejmc on February 26, 2002, at 16:48:55

> There was a person on PB who was in the selegiline patch study. He said that Bodkin told him that Parnate was "too toxic" to be used transdermally (whatever that means).

It might mean that Parnate causes skin problems if you try to administer it transdermally. Or it might just refer to Parnate's apparent pressor effect (which makes it less likely to be considered as a first- or second-line AD even if one could eliminate the food-drug interactions).

> Perhaps it's just politics... selegiline is a new drug, the other MAOIs are quite old.

Selegiline isn't *that* new (its patent has expired). But anyway, regardless of which MAOI was used, the transdermal delivery system would be patentable even though the patent on the drug has expired. (Similarly, controlled release technology is patentable; for example, when the patent runs out on Effexor, you still won't be able to get generic Effexor XR. *sigh*)

> (If the selegiline patch is a success, we might see the release of other MAOI patches...)

I believe that Dr. Bodkin told me several years ago that he expected the selegiline patch to be approved within a year. If my memory is correct (I may be thinking of a different drug, mind you), this doesn't bode well.

-elizabeth


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