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Re: Effexor *no good* for 'anxiety/GAD'...

Posted by Frankie on February 15, 2002, at 18:36:25

In reply to Effexor *no good* for 'anxiety/GAD'..., posted by jay on February 15, 2002, at 17:54:23

> Got this abstract from medline, and it is one of the first to give a outward "thumbs down" to Effexor for "Generalised Anxiety Disorder". The article mentions benzos are *still* first-line treatment, period. As I am coming off of Effexor and using benzos, things sure as hell feel much better! Come to think of it, I have always felt better on benzos than on ANY a.d. Plus, I really can't understand the bizzare and far more dangerous reasoning in using more harmful drugs like antipsychotics over safe and cheap benzos.
>
> Prescrire Int 2001 Oct;10(55):131--4 Related Articles, Books
>
> Venlafaxine and generalised anxiety disorder: new preparation. Minimise recourse to drugs.
>
> (1) Generalised anxiety disorder is defined as excessive anxiety for at least 6 months. (2) Management is based primarily on psychological measures, with the aim of limiting recourse to drugs. The reference drugs are benzodiazepines. The treatment period should be as short as possible, to avoid adverse effects such as sedation and dependence. (3) Venlafaxine is a non tricyclic, non MAOI antidepressant. A sustained-release formulation has just been granted marketing authorisation in France for generalised anxiety disorder. (4) The clinical assessment file on venlafaxine in this indication includes results from two 8-week trials and a placebo-controlled trial with 6 months follow-up. The trials showed a significant improvement with venlafaxine on standard anxiety scales, but the clinical impact (at best moderate) has been poorly assessed. We found no comparison between venlafaxine and benzodiazepines. (5) In one trial venlafaxine was no more effective than buspirone. (6) The most frequent adverse effects of venlafaxine are gastrointestinal disorders, insomnia and dizziness. Venlafaxine carries a risk of drug interactions and withdrawal symptoms. (7) In practice, venlafaxine provides nothing new in the treatment of generalised anxiety disorder. The reference drug treatment remains a benzodiazepine.


I agree with you that the Benzo's are the safest and cheapest way to control anxiety. The only drawbacks are that they don't last long, and unless you combine them with a good serotonin-based antidepressant, they don't work as effectively. But, then again, I have primary OCD symptoms and the Benzo's don't touch that! Even so, you will get better results with Klonopin, etc... if you find the right antidepressant to combine it with. There will be a lower risk of building a tolerance over time too. Effexor was probably too stimulating with the norepinephrine elevation. Try another antidepressant. That is just my advice.

Frankie.


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poster:Frankie thread:94313
URL: http://www.dr-bob.org/babble/20020215/msgs/94319.html