Posted by BobS. on December 24, 2001, at 9:21:20
In reply to Sorry for Mistakes -- It's Late » BobS., posted by Ron Hill on December 24, 2001, at 1:29:15
Ron,
Thanks for the multiple follow-ups. I wouldn't call it anal, just a nice guy.
> Bob S:
>
> I apparently sent my previous post twice and also gave the wrong home page address for Genelex. Oh well, I'm sure you found your way from the ordering page back to the home page. I wanted to include the home page link because they also have some other useful information on their site in addition to the test kit ordering.
>
> For sake of completeness, let me try again:
>
> Home Page: http://www.healthanddna.com/
>
> There! That feels much better now that the anal OCD component of my personality has been satisfied by making the corrections!
>
> -- Ron
> ------------------------------------------
>
>
> > Cam,
> > Are you saying that individuals who are "polymorphic for CYP-2D6" are more susceptable to SSRI withdrawal? If so, how does one determine if they harbor this genetic variation?
> > Thanks,
> > BobS.
> > > IsoM - I would think that SRIs would force our bodies to produce more serotonin. SRIs block the reuptake of serotonin back into the presynaptic neuron, so the body is unable the reuse the neurotransmitter. The serotonin "trapped" in the gap is, for the most part, metabolized, but the levels of serotonin in the gap are still going to be higher while taking the antidepressant than they would be after the antidepressant is stopped. This would result in the serotonergic withdrawl syndrome that is seen; and the less serotonin the body is producing would result in more severe withdrawl effects. This would be exacerbated in those people who also are polymorphic for CYP-2D6 (ie. have multiple copies of the cytochrome-P450-2D6 enzyme gene).
> > >
> > > This mechanism is different from adding levothyroxin (Synthroid™) in hypothyroidism, as you are not adding serotonin to the body with SRIs, you are blocking it's reuptake. The body is still responsible for producing all the serotonin that it is using.
> > >
> > > That's the way I see it, anyway. - Cam
poster:BobS.
thread:3670
URL: http://www.dr-bob.org/babble/20011222/msgs/87803.html