Posted by JohnX2 on December 1, 2001, at 5:51:11
This looks interesting.
I get an unexplained sustained anti-depressant effect
from the anti-histamine chlorpheniramine maleate.
I found this abstract as well as others discussing
the stimulant properties of h1 antagonists.-john
Increased levels of extracellular dopamine in neostriatum and nucleus accumbens after histamine H1 receptor blockade.
Naunyn Schmiedebergs Arch Pharmacol 1998 Oct;358(4):423-9 (ISSN: 0028-1298)Dringenberg HC; de Souza-Silva MA; Schwarting RK; Huston JP [Find other articles with these Authors]
Department of Psychology, Queen's University, Kingston, Ontario, Canada.The dopaminergic system plays a central role in the processing of reward or reinforcement since drugs that have reinforcing properties all share the ability to elevate dopamine (DA) levels in the
nucleus accumbens or neostriatum. Histamine H1 receptor antagonists are known to have reinforcing effects in humans and laboratory rats. Here, we examined the effect of systemic (i.p.)
treatment with two H1 antagonists, chlorpheniramine and pyrilamine, on the extracellular levels of DA and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in
the neostriatum and nucleus accumbens of urethane-anesthetized rats. Dopamine and metabolites were measured using in vivo microdialysis and HPLC with electrochemical detection. Saline
injections did not produce significant effects on DA, DOPAC, or HVA levels in the neostriatum or nucleus accumbens. In the neostriatum, chlorpheniramine administration (5 and 20 mg/kg)
produced a sustained increase in DA to approximately 140 and 180% of pre-injection baseline levels, respectively. In the nucleus accumbens, chlorpheniramine (20 mg/kg) produced a transient
increase in DA levels to about 300% of baseline. In both the neostriatum and nucleus accumbens, DOPAC and HVA decreased after chlorpheniramine treatment. Pyrilamine administration (10
and 20 mg/kg) produced a sustained increase in neostriatal DA levels to 140 and 165%, respectively, and accumbens DA increased transiently to 230% after a dose of 20 mg/kg. Levels of
neostriatal and accumbens DOPAC and HVA decreased after pyrilamine treatment. These results show that H1 antagonists can potently enhance DA levels in the neostriatum and nucleus
accumbens of urethane-anesthetized rats. The neurochemical effects on DA and its metabolites seen here (increased DA, decreased DOPAC and HVA) are similar to those commonly observed
with drugs of abuse (e.g. psychostimulants). The interaction of H1 antagonists with dopaminergic transmission may explain the reinforcing effects and abuse potential associated with these
compounds.
poster:JohnX2
thread:85709
URL: http://www.dr-bob.org/babble/20011123/msgs/85709.html