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Re: Refractary bipolar depression To Scott !!!

Posted by jazzdog on November 9, 2001, at 11:23:35

In reply to Re: Refractary bipolar depression To Scott !!!, posted by JohnX2 on November 8, 2001, at 21:21:06

>
> I heard about this topomax + lamictal combo
> and am also very curious. Seems they work
> orhoganally, one focusing on NMDA (lamictal) and
> the other AMPA and GABAa.

Hi John - I'm just learning a bit about brain chemistry, so forgive the naive questions. Is lamictal an NMDA receptor agonist? Is that why it works to enhance cognition and treat depersonalization / derealization? I've just started a tiny dose of lamictal - 6.5 mg to tritrate slowly up to 150 + - along with 50 mg sertraline to treat my derealization and poor cognition. I've also got lifelong depression, so any help there will be good too. The thing is, I could swear that my head cleared for about half an hour the first day I took it. Is this possible on such a tiny dose, or am I imagining things? I'm usually pretty good at self-assessment for drug reactions, so I'm hoping it's the former. Lamictal is the only treatment so far for chronic derealization, and I so badly want to escape this waking dream. Thanks - Jane


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poster:jazzdog thread:83508
URL: http://www.dr-bob.org/babble/20011104/msgs/83659.html