Posted by SLS on October 16, 2001, at 19:14:51
In reply to Re: California Rocket Fuel+++ » SLS, posted by Elizabeth on October 16, 2001, at 18:15:04
> > Perhaps you can add the drugs in the same order stepwise while continuing desipramine, perhaps leaving it in place as a substitute for bupropion to start with.
>
> That's a thought, although Wellbutrin SR would probably be more tolerable. I would taper off the DMI as I started the new stuff.
>
> > I don’t know if one can think of Cylert as being a substitute for, or analogous to, Provigil. I don’t think Provigil acts directly upon dopaminergic neurons.
> I think it's a DA reuptake inhibitor (a more potent one than has been implied, that is).No. I'm pretty sure modafinil doesn't inhibit at all the reuptake of dopamine at therapeutic dosages, and binds with low affinity to the DA transporter.
> And I don't think it's known just what Cylert does.
In the days before the flood, pemoline was considered to promote the passive release of dopamine presynaptically. It did not promote vesicular release.
I don't know if it is relevant, but the majority of patients who responded in the small open-label study of modafinil-augmentation often cited were taking bupropion. I think this was more the result of patient selection than rate of response.
- ScottClin Psychiatry 2000 May;61(5):378-81 Related Articles, Books
Modafinil augmentation of antidepressant treatment in depression.Menza MA, Kaufman KR, Castellanos A.
poster:SLS
thread:81334
URL: http://www.dr-bob.org/babble/20011015/msgs/81429.html