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Re: Anybody tried clonidine (Catapres) for depression? » SLS

Posted by Elizabeth on October 12, 2001, at 10:43:21

In reply to Re: Anybody tried clonidine (Catapres) for depression?, posted by SLS on October 12, 2001, at 1:48:21

> Generally, people don’t fail to respond to 40 or so antidepressants. One might entertain the idea that the properties of those drugs that are to be effective in my case will deviate substantially from – and might even be in opposition to – those that others find helpful.

Well said. I agree. I think that it might be worthwhile for you to try clonidine or guanfacine.

> Regarding buspirone, I am guessing that its ability to act as a 5-HT1a partial agonist might be most important when used as an augmentor to antidepressants.

It has AD activity on its own when used at high doses (45-90 mg/day). There are also clinical trials of gepirone (a related drug) for depression presently being run in the US, FWIW. I've seen a couple of trials of it and they looked promising.

-elizabeth


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