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Re: Reboxetine - No Go-- SLS

Posted by galtin on October 7, 2001, at 17:34:34

In reply to Re: Reboxetine - No Go galtin, posted by SLS on October 7, 2001, at 10:48:52

> > > So what IS the status of Reboxetine? Heck, I would have thought it would be available by now!
> > > PattyG
> >
> >
> > I think that the FDA turned Reboxetine down.If this is what happened, does anybody know why?
> >
> >
> > galtin
>
>
> I don't know that it has been turned down for a second time. It was turned down over a year ago because the only clinical trial performed in the US found it to be no better than placebo. However, it was determined that this was a "failed" study (invalid) because it also found Prozac to be no better than placebo - which we know is certainly false. The FDA thus mandated that another series of clinical trials be conducted in the US before it would be granted approval. I have no idea where they are with any of that.
>
> Personally, I have not been terribly impressed with reboxetine as far as the number of people who respond well to it, although, obviously, some do. I can think of no reason not to try it. However, be wary that this drug seems to have some liability to make depression dramatically worse for some people.
>
> Good luck.
>
>
> - Scott

Scott- The FDA rejection you mention is the one I was thinking of, though it doesn't seem like a year. I was not aware of round two. Since my depressions seem to involve primarily norepinephrine, I had been interested in the Reboxetine. But your comments throw a new light on things. I don't need to try any medications that WORSEN depression. Thanks for the info.


galtin


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