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Re: Monominergic theories could be horse hockey » stjames

Posted by SLS on September 22, 2001, at 15:38:46

In reply to Re: Monominergic theories could be horse hockey, posted by stjames on September 22, 2001, at 14:40:57

> > I am not saying they are for everybody. But they could be useless. I know with my form of depression. Levels of seretonin,dopamine and NE are not a factor. Its a dysfunction in my circadian rythmn. Monominergic theories have been around for 50 + years and they are no closer to being proven than ever. Keep well, look after yourselves.
>
> James here.....
>
> Monoamines have everything to do with one cause of depression. Given that every AD effects them, clearly Monoamines have something to do with mood. No question here. It is "horse hockey" to
> say that is a lack (or too much) of a Monoamine that causes mood problems, by themselves. This is where the theory fails as it is not complex enough.
>
> james


Hi James,

I agree.

I know I've said this before, but for monoamine neurotransmitter-type stuff, I get the feeling that pushing the system in one direction or another might be forcing a "reset" of a synaptic equilibrium that, if one is lucky, results in a better reflection of the system's genetically intended functional design.

Examples:

fluoxetine - > 5-HT reuptake inhibition
tianeptine - > 5-HT reuptake acceleration

fluoxetine - > increases 5-HT2 receptor stimulation
nefazodone - > decreases 5-HT2 receptor stimulation

What do you think? Simplistic, I know, but perhaps worthy of provoking thought?


- Scott

 

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