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Re: Marplan » Elizabeth

Posted by Grouch on September 9, 2001, at 21:38:28

In reply to Re: Marplan, posted by Elizabeth on September 8, 2001, at 22:16:43

> > MARPLAN was considered the "weakest" of the three other major MAOIs. Roche discontinued it when sales dropped (typical!).
>
> Especially typical of Roche. I think that the doses used in the past were found to be subtherapeutic.

Marplan was the MAO that really got off on the wrong foot. Several early studies showed it to be a less than spectacular antidepressant, so doctors shied away from it. However, it was later recognized that these studies were significantly flawed. There was also concern that Marplan might be toxic to the liver like its sister drug isoniazid (for TB), though time has shown this rarely to be a problem.

> > MARPLAN also happens to be one of the character names of some alien in an old Star Trek episode.
>
> Dude! Which ep?
>
> > What? No infringement litigation against Captain Kirk? I'm shocked! Someone call Johnny Cochran, quickly!
>
> Which came first: Trek ('66) or isocarboxazid? (I think Nardil and Parnate were first marketed in, respectively, '59 and '63.)

There are Medline references to isocarboxazid as far back as '64 -- pre-Star-Trek era.


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