Posted by Sunnely on August 31, 2001, at 19:12:39
In reply to Re: Duda Question » JohnL, posted by Duda on August 30, 2001, at 16:56:12
> Cam...Thanks. You mentioned something about genetics. My Grandmother nearly died from NMS after a lifetime of typical APs. She is schizophrenic.
> Should I take extra precaution?
As Cam mentioned above, a family history of NMS (neuroleptic malignant syndrome) puts you at higher risk for NMS. But this risk alone is probably not enough to cause NMS as it usually occurs due to a combination of factors. Not everyone who has a family history of NMS will develop it when treated with a neuroleptic (antipsychotics). There were also patients who developed NMS from one particular neuroleptic and were successfully re-challenged with another neuroleptic or even same neuroleptic. Although neuroleptics have been commonly implicated, other non-neuroleptics have been found to be the culprits. For example, metoclopramide (Reglan) has been reported to induce NMS; abrupt discontinuation of antiparkinsonian drugs such as levodopa also reported to induce NMS; abrupt discontinuation of anticholinergic drug also implicated.
The risk of NMS in someone on neuroleptic rises if the following conditions are concomitantly present dehydration, agitation, mood disorders, brain damage, withdrawal states, use of rapid dose titration (escalation) and use of intramuscular injections.
Virtually all antipsychotics (old and new) have been reported to cause NMS.
For more info on NMS, go to:
poster:Sunnely
thread:76831
URL: http://www.dr-bob.org/babble/20010828/msgs/77150.html