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Re: Edronax - had it !

Posted by JohnL on August 31, 2001, at 5:50:11

In reply to Re: Edronax - had it ! » JohnL, posted by SalArmy4me on August 29, 2001, at 15:54:02

> How can you prove that adrafinil works on norepinephrine?

Good question. Unfortunately I can't prove it. There is a terrible shortage of good information on Adrafinil in the world of literature. However, the literature that does exist states noradrenergic action. Since there is nothing else to go on, and no opposing viewpoints in literature, I have to take it at face value. Probably the strongest evidence would be the manufacturer's label, which says Adrafinil is an alpha-1 agonist, which is part of the noradrenergic chemistry. Adrafinil supposedly mimics norepinephrine, and binds directly to norepinephrine receptors. It gives the benefits of increased NE without the side effects of increased NE. But like I said, that is just a unanimous finding of the literature out there. SLS has indicated that Adrafinil is not an alpha-1 agonist, that it instead works on other chemistries. That may or may not be true. What he states is not found in any literature. Even with all the shortcomings, I have no choice except to go with existing literature. The most credible literature as I see it is the manufacturer's label.

Years ago it was considered fact that ulcers were caused by stress and improper diets. Then they discovered a bacteria was involved. So even when we in our grandious wisdom believe something to be true without question, it is not unusual to see it later called into question. This also applies to all drugs and just about any topic you can think of. The best we can do is go with current existing data until stronger proof comes along. At this time, all existing data suggests noradrenergic action for Adrafinil. It mimics norepinephrine.

Someone else asked about proof of synergy between Prozac and Adrafinil. There is no proof in literature. I am simply going on observations from this board. Several people have noticed the same synergy that I have with Prozac, but not with other SSRIs. Purely anecdotal, but purely promising as well. I do not believe they were flukes or mere coincidence. There is something to it.

But back to the original topic of this thread, I still think Reboxetine stinks. Just my opinion, again based on anecdotal evidence from this board.
John


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